Masashi Yanagisawa Selected Research

Sleepiness

9/2023	Face validation and pharmacologic analysis of Sik3Sleepy mutant mouse as a possible model of idiopathic hypersomnia.
1/2019	Toward the Mysteries of Sleep.
11/2018	[Development of a Therapeutic Drug for Narcolepsy].
1/2018	Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats.
2/2014	Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.
4/2008	An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients.
7/2004	Behavioral state instability in orexin knock-out mice.

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Masashi Yanagisawa Research Topics

Disease

33	Narcolepsy 01/2024 - 06/2002
16	Cataplexy 01/2022 - 06/2003
14	Sleep Wake Disorders 01/2023 - 06/2002
11	Hypertension (High Blood Pressure) 12/2019 - 08/2002
8	Obesity 10/2022 - 12/2003
7	Disorders of Excessive Somnolence (Hypersomnia) 01/2024 - 04/2008
7	Sleepiness 09/2023 - 07/2004
7	Cardiomegaly (Heart Hypertrophy) 11/2022 - 02/2004
7	Body Weight (Weight, Body) 10/2019 - 08/2004
6	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2023 - 01/2017
6	Inflammation (Inflammations) 10/2022 - 01/2005
6	Insulin Resistance 11/2016 - 05/2003
5	Fibrosis (Cirrhosis) 10/2022 - 06/2010
5	Pulmonary Hypertension 01/2021 - 04/2002
5	Sleep Deprivation 01/2021 - 12/2014
5	Pulmonary Arterial Hypertension 01/2021 - 10/2012
5	Neoplasms (Cancer) 12/2019 - 08/2008
5	Hypertrophy 09/2014 - 02/2004
4	Hypoxia (Hypoxemia) 01/2021 - 04/2002
4	Pain (Aches) 05/2016 - 01/2005
4	Metrorrhagia (Spotting) 11/2004 - 09/2002
3	Nervous System Diseases (Neurological Disorders) 09/2023 - 06/2003
3	Diabetic Nephropathies (Diabetic Nephropathy) 12/2019 - 04/2006
3	Heart Failure 12/2019 - 01/2014
3	Hypothermia 01/2016 - 02/2009
3	Albuminuria 05/2014 - 04/2006
3	Wounds and Injuries (Trauma) 01/2014 - 06/2004
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2009 - 12/2003
3	Chronic Kidney Failure (Chronic Renal Failure) 01/2006 - 06/2004
2	Idiopathic Hypersomnia 01/2024 - 09/2023
2	Parasomnias (Parasomnia) 09/2023 - 11/2020
2	Osteoporosis 08/2023 - 06/2014
2	Mania (Manias) 01/2023 - 06/2020
2	Alzheimer Disease (Alzheimer's Disease) 03/2022 - 12/2014
2	AIDS-Related Complex (ARC) 12/2020 - 03/2004
2	Jet Lag Syndrome 10/2019 - 11/2018
2	Type 2 Diabetes Mellitus (MODY) 11/2016 - 01/2016
2	Sclerosis 01/2016 - 05/2014
2	Systemic Scleroderma (Systemic Sclerosis) 01/2016 - 01/2014
2	DiGeorge Syndrome (Syndrome, DiGeorge) 10/2010 - 09/2003
2	Hyperphagia (Overeating) 05/2010 - 05/2003
2	Weight Gain 02/2009 - 08/2004
2	Sleep Apnea Syndromes (Sleep Apnea) 02/2008 - 01/2007
2	Hyperalgesia 07/2005 - 01/2005
2	Cardiomyopathies (Cardiomyopathy) 04/2005 - 08/2002
2	Heart Diseases (Heart Disease) 04/2005 - 08/2002
1	Cardiac Arrhythmias (Arrythmia) 04/2024
1	Central Nervous System Diseases (CNS Diseases) 01/2024
1	Ventricular Tachycardia 08/2023

Drug/Important Bio-Agent (IBA)

47	OrexinsIBA 09/2023 - 06/2002
23	Endothelin-1 (Endothelin 1)IBA 01/2016 - 08/2002
14	NeuropeptidesIBA 12/2016 - 06/2002
13	Orexin ReceptorsIBA 09/2023 - 03/2004
13	Endothelins (Endothelin)IBA 12/2019 - 04/2002
9	Peptides (Polypeptides)IBA 01/2021 - 04/2003
8	Glucose (Dextrose)FDA LinkGeneric 12/2019 - 05/2003
7	Endothelin Receptors (Endothelin Receptor)IBA 11/2022 - 01/2010
7	Proteins (Proteins, Gene)FDA Link 12/2020 - 01/2002
7	Endothelin B ReceptorIBA 08/2006 - 04/2002
6	Messenger RNA (mRNA)IBA 12/2020 - 04/2002
6	Insulin (Novolin)FDA Link 11/2016 - 05/2003
5	Ataxin-3IBA 03/2010 - 05/2004
4	Orexin Receptor AntagonistsIBA 01/2023 - 01/2019
4	LeptinIBA 01/2012 - 03/2004
4	SaltsIBA 08/2008 - 05/2003
3	YNT-185IBA 09/2023 - 01/2017
3	suvorexantIBA 01/2021 - 11/2016
3	Endothelin Receptor AntagonistsIBA 11/2017 - 08/2008
3	Cholinergic Agents (Cholinergics)IBA 01/2016 - 04/2011
3	CollagenIBA 01/2016 - 10/2012
3	Streptozocin (Streptozotocin)FDA Link 05/2014 - 04/2006
3	ReninIBA 04/2006 - 08/2004
3	A 192621IBA 01/2005 - 09/2002
2	CalciumIBA 08/2023 - 01/2020
2	Hypnotics and Sedatives (Sedatives)IBA 01/2023 - 11/2019
2	LipopolysaccharidesIBA 10/2022 - 12/2016
2	Dopamine (Intropin)FDA LinkGeneric 06/2020 - 08/2011
2	AutoantibodiesIBA 12/2019 - 01/2009
2	AntibodiesIBA 12/2019 - 08/2013
2	CytokinesIBA 12/2016 - 01/2016
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2016 - 01/2014
2	Drinking WaterIBA 01/2016 - 04/2004
2	Connective Tissue Growth FactorIBA 01/2014 - 10/2012
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2012 - 10/2004
2	Superoxides (Superoxide)IBA 04/2012 - 06/2010
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2012 - 12/2003
2	LigandsIBA 09/2006 - 08/2004
2	SodiumIBA 04/2006 - 08/2004
2	4-nitrophenethyl bromide (NPB)IBA 07/2005 - 05/2003
2	AtrasentanIBA 01/2005 - 08/2004
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 08/2004 - 06/2003
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 04/2024
1	Genetic Markers (Genetic Marker)IBA 01/2024
1	NucleotidesIBA 01/2024
1	DNA (Deoxyribonucleic Acid)IBA 01/2024
1	N-(4-aminophenethyl)spiroperidol (NAPS)IBA 09/2023
1	Denosumab FDA Link 08/2023

Therapy/Procedure

11	Therapeutics 01/2022 - 01/2006
2	Ligation 04/2009 - 10/2002
1	Extracorporeal Membrane Oxygenation 08/2023